| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-03-13 |
| タイトル |
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タイトル |
A chemical approach to extend flower longevity of Japanese morning glory via inhibition of master senescence regulator EPHEMERAL1 |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
SHIBUYA, Kenichi
| en |
SHIBUYA, Kenichi
Institute of Vegetable and Floriculture Science, National Agriculture and Food Research Organization (NARO)
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Search repository
NOZAWA, Akira
TAKAHASHI, Chikako
| en |
TAKAHASHI, Chikako
Proteo-Science Center (PROS), Ehime University
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Search repository
SAWASAKI, Tatsuya
| en |
SAWASAKI, Tatsuya
Proteo-Science Center (PROS), Ehime University
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Search repository
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Petal senescence in flowering plants is a type of programmed cell death with highly regulated onset and progression. A NAM/ATAF1,2/CUC2 transcription factor, EPHEMERAL1 (EPH1), has been identified as a key regulator of petal senescence in Japanese morning glory (Ipomoea nil). Here we used a novel chemical approach to delay petal senescence in Japanese morning glory by inhibiting the DNA-binding activity of EPH1. A cell-free high-throughput screening system and subsequent bioassays found two tetrafluorophthalimide-based compounds, Everlastin1 and Everlastin2, that inhibited the EPH1-DNA interaction and delayed petal senescence. The inhibitory mechanism was due to the suppression of EPH1 dimerization. RNA-sequencing analysis revealed that the chemical treatment strongly suppressed the expression of programmed cell death- and autophagy-related genes. These results suggest that a chemical approach targeting a transcription factor can regulate petal senescence. |
|
言語 |
en |
| 書誌情報 |
en : Nature Plants
巻 10,
号 9,
p. 1377-1388,
発行日 2024-09
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| 出版者 |
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出版者 |
Springer Nature |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2055-0278 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA1273934X |
| PubMed番号 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
PMID |
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関連識別子 |
39209993 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1038/s41477-024-01767-z |
| 権利 |
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権利情報 |
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1038/s41477-024-01767-z |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
Accepted Manuscript_AA1273934X_10_1377–1388.pdf (2 MB)
