| 著者 |
WATANABE, Takao
| en |
WATANABE, Takao
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine
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TOKUMOTO, Yoshio
| en |
TOKUMOTO, Yoshio
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine
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OCHI, Hironori
| en |
OCHI, Hironori
Center for Liver-Biliary-Pancreatic Diseases, Matsuyama Red Cross Hospital
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MASHIBA, Toshie
| en |
MASHIBA, Toshie
Center for Liver-Biliary-Pancreatic Diseases, Matsuyama Red Cross Hospital
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TADA, Fujimasa
| en |
TADA, Fujimasa
Department of Gastroenterology, Ehime Prefectural Central Hospital
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HIRAOKA, Atsushi
| en |
HIRAOKA, Atsushi
Department of Gastroenterology, Ehime Prefectural Central Hospital
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KISAKA, Yoshiyasu
| en |
KISAKA, Yoshiyasu
Department of Gastroenterology, Matsuyama Shimin Hospital
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TANAKA, Yoshinori
| en |
TANAKA, Yoshinori
Department of Gastroenterology, Matsuyama Shimin Hospital
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YAGI, Sen
| en |
YAGI, Sen
Department of Gastroenterology, Saiseikai Imabari Hospital
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NAKANISHI, Seiji
| en |
NAKANISHI, Seiji
Department of Gastroenterology, Ehime Prefectural Imabari Hospital
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SUNAGO, Kotaro
| en |
SUNAGO, Kotaro
Department of Gastroenterology, Uwajima City Hospital
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YAMAUCHI, Kazuhiko
| en |
YAMAUCHI, Kazuhiko
Department of Gastroenterology, Uwajima City Hospital
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HIGASHINO, Makoto
| en |
HIGASHINO, Makoto
Department of Internal Medicine, Saiseikai Matsuyama Hospital
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HIROOKA, Kana
| en |
HIROOKA, Kana
Department of Gastroenterology, National Hospital Organization Ehime Medical Center
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TANGE, Masaaki
| en |
TANGE, Masaaki
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine
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YUKIMOTO, Atsushi
| en |
YUKIMOTO, Atsushi
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine
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MORITA, Makoto
| en |
MORITA, Makoto
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine
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OKAZAKI, Yuki
| en |
OKAZAKI, Yuki
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine
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HIROOKA, Masashi
| en |
HIROOKA, Masashi
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine
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ABE, Masanori
| en |
ABE, Masanori
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine
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HIASA, Yoichi
| en |
HIASA, Yoichi
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine
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内容記述 |
Background The clinical course of esophagogastric varices (EGV) after sustained virological response (SVR) with direct-acting antiviral (DAA) therapy has not been clearly elucidated. The predictors for the worsening/improvement of EGV after SVR with DAA therapy were investigated. Methods Of the cirrhosis patients who achieved SVR with DAA therapy, 328 patients who underwent endoscopic examinations both before and after DAA therapy were enrolled. The predictors of EGV worsening or improvement were investigated. Results Multivariate analysis identified a history of ascites retention, albumin at baseline, and MELD score at baseline as independent factors that contributed to EGV exacerbation. On multivariate analysis, two factors, BMI and platelet count, were related to EGV improvement. An integrated scoring system was created using these risk factors with or without weighting according to each hazard ratio, and the patients were divided into three groups. A scoring system with weighting of each factor appeared to be more useful, with fewer intermediate patients and more cases classified into the low-risk and high-risk groups. Conclusions Esophagogastric varices after SVR have a varied clinical course. Using this scoring system that can accurately predict EGV outcomes in clinical settings, it may be feasible to establish a risk-based EGV surveillance plan following SVR. |
AA10988015_60_2_222-234.pdf (517 KB)
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