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Heavy oil fractions induce negative influences on mouse immune system
https://ehime-u.repo.nii.ac.jp/records/2002275
https://ehime-u.repo.nii.ac.jp/records/2002275e0344996-6c93-4b2a-b449-782feb236636
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00002808_34_459.pdf
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2012-02-20 | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| タイトル | Heavy oil fractions induce negative influences on mouse immune system | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 言語 | ||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | Immune response | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | Oral administration | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | Splenocyte | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | Estrogenic activity | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | Flowcytometry | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | Water-soluble fraction (WSF) | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||
| 著者 |
NISHIMOTO, Sogo
× NISHIMOTO, Sogo
× KANDA, Kota
× YAMAWAKI, Manami
× OKABE, Masaaki
× AKIYAMA, Koichi
× KAKINUMA, Yoshimi
× SUGAHARA, Takuya
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| 抄録 | ||||||||||||||||||||
| 内容記述 | It is well known that heavy oil pollution results in various negative impacts on the marine environment. Although there is a low possibility of direct exposure to heavy oil, the chemical substances contained in heavy oil may be released into the environment and accumulated by marine organisms which in turn can be taken by humans via the food chain. In this study, we examined the biological risk of heavy oil extract using the common mouse, whose genetic backgrounds and immune system are well known and relatively homologous to humans. Water-soluble fraction (WSF) was extracted from heavy oil with water and the extract orally administrated to female or male mice for 7 days. In the WSF administrated group, cystoma-like formation was observed in the ovary in approximately 80% of female mice. On the other hand, we found that the prostate gland size in male mice was markedly reduced in comparison with male control mice. Continuous administration of WSF for 28 days resulted in continued hypertrophy of the cystoma around the ovary and atrophy in the prostate gland. In addition, it was revealed that chemical substances within WSF have estrogenic activity. A major component of heavy oil, polycyclic aromatic hydrocarbons (PAHs), is known to present estrogenic activity. It is likely that the cystoma-like formation in female mice and atrophy of prostate gland in male resulted of estrogenic substances present in the WSF which might be the PAHs. | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 書誌情報 |
en : The Journal of Toxicological Sciences 巻 34, 号 5, p. 459-468, 発行日 2009-10 |
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| 出版者 | ||||||||||||||||||||
| 出版者 | The Japanese Society of Toxicology | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| ISSN | ||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||
| 収録物識別子 | 0388-1350 | |||||||||||||||||||
| 書誌レコードID | ||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||
| 収録物識別子 | AN00002808 | |||||||||||||||||||
| PubMed番号 | ||||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||||
| 関連識別子 | 19797854 | |||||||||||||||||||
| DOI | ||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||
| 関連識別子 | 10.2131/jts.34.459 | |||||||||||||||||||
| 著者版フラグ | ||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||
| 日本十進分類法 | ||||||||||||||||||||
| 主題Scheme | NDC | |||||||||||||||||||
| 主題 | 491.5 | |||||||||||||||||||
